B cell development pathways.

  title={B cell development pathways.},
  author={R. Hardy and K. Hayakawa},
  journal={Annual review of immunology},
  • R. Hardy, K. Hayakawa
  • Published 2001
  • Biology, Medicine
  • Annual review of immunology
  • B cell development is a highly regulated process whereby functional peripheral subsets are produced from hematopoietic stem cells, in the fetal liver before birth and in the bone marrow afterward. Here we review progress in understanding some aspects of this process in the mouse bone marrow, focusing on delineation of the earliest stages of commitment, on pre-B cell receptor selection, and B cell tolerance during the immature-to-mature B cell transition. Then we note some of the distinctions in… CONTINUE READING
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