B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.

@article{Hauser2008BcellDW,
  title={B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.},
  author={Stephen L. Hauser and Emmanuelle Waubant and Douglas L. Arnold and Timothy L. Vollmer and Jack P. Antel and Robert J. Fox and Amit Bar-Or and Michael A. Panzara and Neena Sarkar and Sunil Agarwal and Annette M Langer-Gould and Craig H. Smith},
  journal={The New England journal of medicine},
  year={2008},
  volume={358 7},
  pages={
          676-88
        }
}
BACKGROUND There is increasing evidence that B lymphocytes are involved in the pathogenesis of multiple sclerosis, and they may be a therapeutic target. Rituximab, a monoclonal antibody, selectively targets and depletes CD20+ B lymphocytes. METHODS In a phase 2, double-blind, 48-week trial involving 104 patients with relapsing-remitting multiple sclerosis, we assigned 69 patients to receive 1000 mg of intravenous rituximab and 35 patients to receive placebo on days 1 and 15. The primary end… 

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