B cell depletion therapy in rheumatic disease.

@article{Edwards2006BCD,
  title={B cell depletion therapy in rheumatic disease.},
  author={Jonathan W. Edwards and Geraldine Cambridge and Maria Jos{\'e} Leandro},
  journal={Best practice & research. Clinical rheumatology},
  year={2006},
  volume={20 5},
  pages={915-28}
}
B cell depletion therapy was introduced for auto-antibody associated rheumatic disease in 1998. Encouraging pilot studies in rheumatoid arthritis were followed by randomised controlled trials confirming major benefit. Licensing for use in patients unable to benefit from tumour necrosis factor alpha (TNFalpha) neutralising agents is envisaged shortly. Open studies in other disorders, in particular systemic lupus erythematosus (SLE), have also suggested benefit and its use in life-threatening… CONTINUE READING

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