B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.

  title={B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody.},
  author={Ronald Herbst and Yue Wang and Sandra Gallagher and Nanette Mittereder and Ellen Kuta and Melissa M. Damschroder and Rob Woods and Daniel C. Rowe and Li Cheng and Kim Oanh Cook and Krista L Evans and Gary Patrick Sims and David S. Pfarr and Michael A. Bowen and William F Dall'acqua and Mark J. Shlomchik and Thomas F. Tedder and Peter Kiener and Bahija Jallal and Herren Wu and Anthony J Coyle},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={335 1},
The pan B-cell surface antigen CD19 is an attractive target for therapeutic monoclonal antibody (mAb) approaches. We have generated a new afucosylated anti-human (hu)CD19 mAb, MEDI-551, with increased affinity to human FcγRIIIA and mouse FcγRIV and enhanced antibody-dependent cellular cytotoxicity (ADCC). During in vitro ADCC assays with B-cell lines, MEDI-551 is effective at much lower mAb concentrations than the fucosylated parental mAb anti-CD19-2. Furthermore, the afucosylated CD19 mAb MEDI… CONTINUE READING


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