B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.

@article{Mohiuddin2012BcellDE,
  title={B-cell depletion extends the survival of GTKO.hCD46Tg pig heart xenografts in baboons for up to 8 months.},
  author={Muhammad M Mohiuddin and Philip C. Corcoran and Avneesh Kumar Singh and Agn{\`e}s Azimzadeh and Robert Franklin Hoyt and Marvin L. Thomas and Michael A. Eckhaus and Carol Seavey and David Lee Ayares and Richard N Pierson and Keith Joseph Horvath},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2012},
  volume={12 3},
  pages={
          763-71
        }
}
Xenotransplantation of genetically modified pig organs offers great potential to address the shortage of human organs for allotransplantation. Rejection in Gal knockout (GTKO) pigs due to elicited non-Gal antibody response required further genetic modifications of donor pigs and better control of the B-cell response to xenoantigens. We report significant prolongation of heterotopic alpha Galactosyl transferase "knock-out" and human CD46 transgenic (GTKO.hCD46Tg) pig cardiac xenografts survival… CONTINUE READING
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