B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.

@article{Hamel2011BCD,
  title={B cell depletion enhances T regulatory cell activity essential in the suppression of arthritis.},
  author={Keith M. Hamel and Yanxia Cao and Susan Ashaye and Yumei Wang and Robert Dunn and Marilyn R. Kehry and Tibor T. Glant and Alison Finnegan},
  journal={Journal of immunology},
  year={2011},
  volume={187 9},
  pages={4900-6}
}
The efficacy of B cell-depletion therapy in rheumatoid arthritis has driven interest in understanding the mechanism. Because the decrease in autoantibodies in rheumatoid arthritis does not necessarily correlate with clinical outcome, other mechanisms may be operative. We previously reported that in proteoglycan-induced arthritis (PGIA), B cell-depletion inhibits autoreactive T cell responses. Recent studies in B cell-depletion therapy also indicate a role for B cells in suppressing regulatory… CONTINUE READING