B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity.

@article{Yanaba2007BCD,
  title={B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity.},
  author={Koichi Yanaba and Yasuhito Hamaguchi and Guglielmo M. Venturi and Douglas A. Steeber and Eugene William St. Clair and Thomas F. Tedder},
  journal={Journal of immunology},
  year={2007},
  volume={179 2},
  pages={1369-80}
}
Rheumatoid arthritis is a systemic autoimmune disease. B cells are likely to play a critical role in arthritis pathogenesis, although it is unclear whether they are necessary for disease induction, autoantibody production, or disease progression. To assess the role of B cells in inflammatory arthritis, B cells were depleted using mouse anti-mouse CD20 mAbs in a mouse model of collagen-induced arthritis. CD20 mAbs effectively depleted mature B cells from adult DBA-1 mice. When B cells were… CONTINUE READING

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