B cell costimulatory molecules as potential biomarkers in HAM/TSP

Current therapy in HAM/TSP includes antiretrovirals and immunomodulators, such as corticosteroids and interferons, with modest clinical benefit. Since there are no validated biomarkers to monitor disease severity (DS), progression or prognosis, we investigated the ex vivo expression of CD80 and CD86 as possible biomarkers, as well as the effect of IFN-a… CONTINUE READING