B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity.

@article{Zhao1998BcellCL,
  title={B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity.},
  author={Hong Xin Zhao and Nathalie Dugas and Claire Mathiot and Alain Delmer and Bernard Dugas and François Sigaux and J P Kolb},
  journal={Blood},
  year={1998},
  volume={92 3},
  pages={1031-43}
}
The expression of different isoforms of nitric oxide synthase (NOS) was investigated in B-cell chronic lymphocytic leukemia (B-CLL) to delineate a possible role for nitric oxide (NO) in the control of apoptosis of the tumoral cells. By reverse transcription-polymerase chain reaction (RT-PCR), all B-CLL cells were found to express spontaneously inducible NOS (iNOS) mRNA, whereas endothelial constitutive NOS (ecNOS) mRNA was undetectable. The iNOS protein was detected by immunofluorescence in the… CONTINUE READING
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