B-cell biology and related therapies in systemic lupus erythematosus.

  title={B-cell biology and related therapies in systemic lupus erythematosus.},
  author={Sadia Ahmed and Jennifer H. Anolik},
  journal={Rheumatic diseases clinics of North America},
  volume={36 1},
  pages={109-30, viii-ix}
Systemic lupus erythematosus (SLE) is a complex disease characterized by numerous autoantibodies and clinical involvement in multiple organ systems. The immunologic events triggering the onset and progression of clinical manifestations have not yet been fully defined, but a central role for B cells in the pathogenesis has been brought to the fore in the last several years. The breakdown of B-cell tolerance is likely a defining and early event in the disease process and may occur by multiple… CONTINUE READING