B cell antigen receptor signaling: roles in cell development and disease.

@article{Gauld2002BCA,
  title={B cell antigen receptor signaling: roles in cell development and disease.},
  author={Stephen B. Gauld and Joseph M. Dal Porto and John C Cambier},
  journal={Science},
  year={2002},
  volume={296 5573},
  pages={
          1641-2
        }
}
Signals propagated through the B cell antigen receptor (BCR) are vital for the development and survival of B lymphocytes in both the bone marrow and the periphery. These signals not only guide maturation and activation but also affect the removal of potentially self-reactive B lymphocytes. Interestingly, these signals are known to be either ligand-independent ("tonic" signals) or induced by ligand (antigen) binding to the BCR. We focus on the problems that occur in B cell development due to… CONTINUE READING
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