B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol.

@article{Antony2004BcellAR,
  title={B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB) via a mechanism that involves diacylglycerol.},
  author={Pierre Antony and James B. Petro and Gianluca Carlesso and Nicholas P. Shinners and John W. Lowe and Wasif Noor Khan},
  journal={Biochemical Society transactions},
  year={2004},
  volume={32 Pt 1},
  pages={
          113-5
        }
}
Engagement of the B-cell antigen receptor (BCR) induces the activation of various transcription factors, including NFAT (nuclear factor of activated T-cells) and NF-kappaB (nuclear factor kappaB), which participate in long-term biological responses such as proliferation, survival and differentiation of B-lymphocytes. We addressed the biochemical basis of this process using the DT40 chicken B-cell lymphoma. We discovered that Bruton's tyrosine kinase (BTK) and phospholipase C-gamma2 (PLC-gamma2… CONTINUE READING
BETA

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