B-cell activation versus tolerance--the central role of immunoglobulin receptor engagement and T-cell help.

@article{Fulcher1997BcellAV,
  title={B-cell activation versus tolerance--the central role of immunoglobulin receptor engagement and T-cell help.},
  author={David A. Fulcher and Antony Basten},
  journal={International reviews of immunology},
  year={1997},
  volume={15 1-2},
  pages={33-52}
}
The critical variables responsible for the decision between activation and tolerance in the B-cell compartment were studied in the well-characterised hen egg lysozyme:antilysozyme transgenic model. Mature B-cells exposed to a low antigenic signal, which resulted in a receptor occupancy of between 5% and 25%, remained 'indifferent' (i.e. were neither activated nor tolerant), had a normal lifespan and recirculated through B-cell follicles. When receptor occupancy reached a critical threshold of… CONTINUE READING

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