B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.

@article{ShulgaMorskaya2004BCF,
  title={B cell-activating factor belonging to the TNF family acts through separate receptors to support B cell survival and T cell-independent antibody formation.},
  author={Svetlana Shulga-Morskaya and Max Dobles and Meghan E Walsh and Lai Guan Ng and Fabienne Mackay and Sambasiva P. Rao and Susan L. Kalled and Martin L. Scott},
  journal={Journal of immunology},
  year={2004},
  volume={173 4},
  pages={2331-41}
}
The TNF-related ligand, B cell-activating factor belonging to the TNF family (BAFF), is necessary for normal B cell development and survival, and specifically binds the receptors transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), B cell maturation Ag (BCMA), and BAFF-R. Similarities between mice completely lacking BAFF and A/WySnJ strain mice that express a naturally occurring mutant form of BAFF-R suggest that BAFF acts primarily through BAFF-R. However… CONTINUE READING

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