B- and T-lymphocyte micronuclei in chimney sweeps with respect to genetic polymorphism for CYP1A1 and GST1 (class Mu).

@article{Carstensen1993BAT,
  title={B- and T-lymphocyte micronuclei in chimney sweeps with respect to genetic polymorphism for CYP1A1 and GST1 (class Mu).},
  author={U Carstensen and A K Alexandrie and Benkt H{\"o}gstedt and Agneta Rannug and Ingrid Bratt and Lars Hagmar},
  journal={Mutation research},
  year={1993},
  volume={289 2},
  pages={187-95}
}
Epidemiological studies have shown an increased incidence of lung cancer, bladder cancer, and esophageal cancer in chimney sweeps, probably due to their exposure to PAH in soot. The work environment for sweeps has, however, improved during the last decades. It was thus important to assess whether the present exposure still may cause genotoxic effects. A further objective was to assess whether genetic polymorphisms in metabolic enzyme activities could explain some of the variation in the… CONTINUE READING

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