B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

  title={B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator},
  author={J. Sedy and Maya Gavrieli and K. Potter and M. Hurchla and R. Lindsley and K. Hildner and S. Scheu and K. Pfeffer and C. Ware and T. Murphy and K. Murphy},
  journal={Nature Immunology},
  • J. Sedy, Maya Gavrieli, +8 authors K. Murphy
  • Published 2005
  • Biology, Medicine
  • Nature Immunology
  • B and T lymphocyte attenuator (BTLA) provides an inhibitory signal to B and T cells. Previously, indirect observations suggested that B7x was a ligand for BTLA. Here we show that BTLA does not bind B7x; instead, we identify herpesvirus entry mediator (HVEM) as the unique BTLA ligand. BTLA bound the most membrane-distal cysteine-rich domain of HVEM, distinct from regions where the ligands LIGHT and lymphotoxin-α bound HVEM. HVEM induced BTLA tyrosine phosphorylation and association of the… CONTINUE READING
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