B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator

@article{ed2005BAT,
  title={B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator},
  author={John R. {\vS}ed{\'y} and Maya Gavrieli and Karen G Potter and Michelle A. Hurchla and R Coleman Lindsley and Kai Hildner and Stefanie Scheu and Klaus Pfeffer and Carl F Ware and Theresa L. Murphy and Kenneth M Murphy},
  journal={Nature Immunology},
  year={2005},
  volume={6},
  pages={90-98}
}
B and T lymphocyte attenuator (BTLA) provides an inhibitory signal to B and T cells. Previously, indirect observations suggested that B7x was a ligand for BTLA. Here we show that BTLA does not bind B7x; instead, we identify herpesvirus entry mediator (HVEM) as the unique BTLA ligand. BTLA bound the most membrane-distal cysteine-rich domain of HVEM, distinct from regions where the ligands LIGHT and lymphotoxin-α bound HVEM. HVEM induced BTLA tyrosine phosphorylation and association of the… CONTINUE READING
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