B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation

@article{Krieg2007BAT,
  title={B and T lymphocyte attenuator regulates CD8+ T cell–intrinsic homeostasis and memory cell generation},
  author={Carsten Krieg and Onur Boyman and Yang-Xin Fu and Jonathan Kaye},
  journal={Nature Immunology},
  year={2007},
  volume={8},
  pages={162-171}
}
B and T lymphocyte attenuator (BTLA) is a negative regulator of T cell activation, but its function in vivo is not well characterized. Here we show that mice deficient in full-length BTLA or its ligand, herpesvirus entry mediator, had increased number of memory CD8+ T cells. The memory CD8+ T cell phenotype resulted from a T cell–intrinsic perturbation of the CD8+ T cell pool. Naive BTLA-deficient CD8+ T cells were more efficient than wild-type cells at generating memory in a competitive… CONTINUE READING
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B and T lymphocyte attenuator and programmed death receptor-1 inhibitory receptors are required for termination of acute allergic airway inflammation

  • Deppong, C. et al. Cutting edge
  • J. Immunol. 176, 3909–3913
  • 2006

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