B and T lymphocyte attenuator down-regulation by HIV-1 depends on type I interferon and contributes to T-cell hyperactivation.

@article{Zhang2011BAT,
  title={B and T lymphocyte attenuator down-regulation by HIV-1 depends on type I interferon and contributes to T-cell hyperactivation.},
  author={Zheng Zhang and Xiangsheng Xu and Ji-yun Lu and Shuye Zhang and Lanlan Gu and Junliang Fu and Lei Jin and Haiying Li and Min Zhao and Jiyuan Zhang and Hao Wu and Lishan Su and Yang-Xin Fu and Fu-sheng Wang},
  journal={The Journal of infectious diseases},
  year={2011},
  volume={203 11},
  pages={1668-78}
}
BACKGROUND Nonspecific T-cell hyperactivation is the main driving force for human immunodeficiency virus (HIV)-1 disease progression, but the reasons why the excess immune response is not properly shut off are poorly defined. METHODS Eighty-five HIV-1-infected individuals were enrolled to characterize B and T lymphocyte attenuator (BTLA) expression and function. Infection and blockade assays were used to dissect the factors that influenced BTLA signaling in vitro. RESULTS BTLA expression on… CONTINUE READING
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