B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1

@inproceedings{Karnowski2012BAT,
  title={B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1},
  author={Alex Karnowski and St{\'e}phane Chevrier and Gabrielle T. Belz and Adele M. Mount and Dianne Emslie and Kathy D’Costa and David M Tarlinton and Axel Kallies and Lynn M Corcoran},
  booktitle={The Journal of experimental medicine},
  year={2012}
}
A strong humoral response to infection requires the collaboration of several hematopoietic cell types that communicate via antigen presentation, surface coreceptors and their ligands, and secreted factors. The proinflammatory cytokine IL-6 has been shown to promote the differentiation of activated CD4(+) T cells into T follicular helper cells (T(FH) cells) during an immune response. T(FH) cells collaborate with B cells in the formation of germinal centers (GCs) during T cell-dependent antibody… CONTINUE READING
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