B and T cell tolerance and autoimmunity in autoantibody transgenic mice.

@article{Yan2002BAT,
  title={B and T cell tolerance and autoimmunity in autoantibody transgenic mice.},
  author={Jun Yan and Mark J. Mamula},
  journal={International immunology},
  year={2002},
  volume={14 8},
  pages={
          963-71
        }
}
One hallmark of systemic lupus erythematosus (SLE) is the presence of autoantibodies directed at a diverse group of proteins of the U1/Sm small nuclear ribonucleoprotein particles (snRNP). Patients with SLE and murine models of this disease generate high titers of affinity mature, isotype-switched autoantibodies characteristic of T cell-dependent immune responses. In this investigation, we made use of anti-snRNP Ig transgenic mice (2-12 Tg) to track regulation of autoreactive B cells in normal… CONTINUE READING

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Regulatory B lymphocytes in humans: a potential role in autoimmunity.

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[The mechanisms of antinuclear antibody production and its pathogenicity in systemic autoimmune diseases].

  • Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology
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