B-Type Natriuretic Peptide Modulates Pulmonary Vein Arrhythmogenesis: A Novel Potential Contributor to the Genesis of Atrial Tachyarrhythmia in Heart Failure.

@article{Lin2016BTypeNP,
  title={B-Type Natriuretic Peptide Modulates Pulmonary Vein Arrhythmogenesis: A Novel Potential Contributor to the Genesis of Atrial Tachyarrhythmia in Heart Failure.},
  author={Yung-Kuo Lin and Yao-Chang Chen and Yi-Ann Chen and Yung-Hsin Yeh and Shih Ann Chen and Yi-Jen Chen},
  journal={Journal of cardiovascular electrophysiology},
  year={2016},
  volume={27 12},
  pages={
          1462-1471
        }
}
BACKGROUND Heart failure (HF) plays a critical role in the genesis of atrial fibrillation (AF). A high B-type natriuretic peptide (BNP) level occurs in patients with HF and in patients with AF. However, the role of BNP in the pathophysiology of AF is not clear. The purposes of this study were to evaluate the effects of BNP on pulmonary vein (PV) arrhythmogenesis. METHODS AND RESULTS Whole-cell patch clamp and fluorescence were used to study the action potential, ionic currents, and calcium… CONTINUE READING