B-S transition in short oligonucleotides.

  title={B-S transition in short oligonucleotides.},
  author={Julia Morfill and Ferdinand K{\"u}hner and Kerstin Blank and Robert Andreas Lugmaier and Julia Sedlmair and Hermann Eduard Gaub},
  journal={Biophysical journal},
  volume={93 7},
Stretching experiments with long double-stranded DNA molecules in physiological ambient revealed a force-induced transition at a force of 65 pN. During this transition between B-DNA and highly overstretched S-DNA the DNA lengthens by a factor of 1.7 of its B-form contour length. Here, we report the occurrence of this so-called B-S transition in short duplexes consisting of 30 basepairs. We employed atomic-force-microscope-based single molecule force spectroscopy to explore the unbinding… CONTINUE READING
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