B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells

@article{Tarasov2008BMYBIE,
  title={B-MYB Is Essential for Normal Cell Cycle Progression and Chromosomal Stability of Embryonic Stem Cells},
  author={Kirill V Tarasov and Yelena S. Tarasova and Wai Leong Tam and Daniel R. Riordon and Steven T. Elliott and Gabriela Kania and Jinliang Li and Satoshi Yamanaka and David G. Crider and Gianluca Testa and Ronald A. Li and Bing Lim and Colin Lawson Stewart and Yie Liu and Jennifer E. van Eyk and Robert P. Wersto and Anna M. Wobus and Kenneth R. Boheler},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={3017 - 3033}
}
BACKGROUND The transcription factor B-Myb is present in all proliferating cells, and in mice engineered to remove this gene, embryos die in utero just after implantation due to inner cell mass defects. This lethal phenotype has generally been attributed to a proliferation defect in the cell cycle phase of G1. METHODOLOGY/PRINCIPAL FINDINGS In the present study, we show that the major cell cycle defect in murine embryonic stem (mES) cells occurs in G2/M. Specifically, knockdown of B-Myb by… CONTINUE READING
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In vitro differentiation of mouse ES cells to muscle cells

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