B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.

@article{Asano2004BLS,
  title={B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.},
  author={Noriko Asano and M. Jack Fujimoto and Norihito Yazawa and Senji Shirasawa and Minoru Hasegawa and Hitoshi Okochi and Kunihiko Tamaki and Thomas F. Tedder and Shinichi Sato},
  journal={The American journal of pathology},
  year={2004},
  volume={165 2},
  pages={
          641-50
        }
}
Systemic sclerosis (SSc) is characterized by fibrosis and autoimmmunity. Peripheral blood B cells from SSc patients specifically overexpress CD19, a critical cell-surface signal transduction molecule in B cells. CD19 deficiency in B cells also attenuates skin fibrosis in the tight-skin (TSK/+) mouse, a genetic model for SSc. Herein we analyzed two transgenic mouse lines that overexpress CD19. Remarkably, 20% increase of CD19 expression in mice spontaneously induced SSc-specific anti-DNA… CONTINUE READING

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