B Cells of HIV-1–Infected Patients Bind Virions through Cd21–Complement Interactions and Transmit Infectious Virus to Activated T Cells

@article{Moir2000BCO,
  title={B Cells of HIV-1–Infected Patients Bind Virions through Cd21–Complement Interactions and Transmit Infectious Virus to Activated T Cells},
  author={Susan Moir and Angela Malaspina and Yuexia Li and Tae-Wook Chun and Tomeka Lowe and Joseph W. Adelsberger and Michael W. Baseler and Linda A. Ehler and Shuying Liu and Richard T. Davey and Jo Ann M. Mican and Anthony S. Fauci},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={192},
  pages={637 - 646}
}
The impact of HIV-associated immunopathogenesis on B cells has been largely associated with indirect consequences of viral replication. This study demonstrates that HIV interacts directly with B cells in both lymphoid tissues and peripheral blood. B cells isolated from lymph node and peripheral blood mononuclear cells (PBMCs) of 4 and 23 chronically infected patients, respectively, demonstrated similar capacities to pass virus to activated HIV-negative PBMCs when compared with CD4(+) cells from… CONTINUE READING

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Latent reservoirs of HIV: obstacles to the eradication of virus.

Proceedings of the National Academy of Sciences of the United States of America • 1999

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