B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren’s Syndrome

  title={B Cells Are Indispensable for a Novel Mouse Model of Primary Sj{\"o}gren’s Syndrome},
  author={Junfeng Zheng and Qiaoniang Huang and Renliang Huang and Fengyuan Deng and Xiaoyang Yue and Junping Yin and Wenjie Zhao and Yan Chen and Lifang Wen and Jun Zhou and R. Huang and Gabriela Riemekasten and Zuguo Liu and Frank Petersen and Xinhua Yu},
  journal={Frontiers in Immunology},
Primary Sjögren’s syndrome (pSS) is characterized by a panel of autoantibodies, while it is not clear whether B cells and autoantibodies play an essential role in pathogenesis of the disease. Here, we report a novel mouse model for pSS which is induced by immunization with the Ro60_316-335 peptide containing a predominant T cell epitope. After immunization, mice developed several symptoms mimicking pSS, including a decreased secretion of tears, lymphocytic infiltration into the lacrimal glands… 
Recent Advances in Mouse Models of Sjögren's Syndrome
This review aims to provide a comprehensive overview of recent advances in the field of experimental Sjögren's syndrome by reviewing mouse models, genetic models, and induced models, in which mice spontaneously develop SS-like disease.
Animal models of Sjögren's syndrome: an update.
Current animal models with primary SS-like symptoms including spontaneous models, genetically modified models, induced models and humanised models are summarized and their contribution to the understanding of SS aetiology and therapies is discussed.
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Insight is given into the molecular mechanisms of autoreactive inflammation in SjS, assist MALT lymphoma diagnosis and allow tracking its response to rituximab.
Advances in Pathogenesis of Sjögren's Syndrome
A systematic review of the literature may clarify the etiology and pathogenesis of SS, as well as provide a theoretical basis for the development of new drugs for the treatment of SS.
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It is reported that ectopic expression of MHC II molecules on glandular cells represents an early presymptomatic event in a mouse model of pSS induced by immunization of Ro60_316-335 peptide emulsified in TiterMax® as an adjuvant.
Peptide-Based Subunit Vaccine Design of T- and B-Cells Multi-Epitopes against Zika Virus Using Immunoinformatics Approaches
It is believed that the use of immunoinformatics methods is a promising strategy against the Zika viral infection in designing an efficacious multiepitope vaccine.
Role of Interleukin-38 in Chronic Inflammatory Diseases: A Comprehensive Review
The expression and biological functions of IL-38 are discussed, especially the role in rheumatic autoimmune diseases, and potential for theoretical basis for clinical trials and drug development in the future is given.
Optical Coherence Tomography Angiography Biomarkers of Retinal Thickness and Microvascular Alterations in Sjogren's Syndrome
In patients with SS, retinal thinning in the macular area—which affects vision—can also reflect the severity of dry eyes in SS and has clinical value for assisted imaging diagnosis.


Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjögren's syndrome.
It is demonstrated that BAFF Tg mice, as they age, develop a secondary pathology reminiscent of Sjögren's syndrome, and altered B cell differentiation and tolerance induced by excess BAFF may be central to SS pathogenesis.
A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.
Autoantibodies against the Second Extracellular Loop of M3R Do neither Induce nor Indicate Primary Sjögren’s Syndrome
The results suggest that the autoantibodies against peptides of the second extracellular loop of M3R are not pathogenic in vivo and they are not suitable as biomarkers for pSS diagnosis.
Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren's syndrome-like sialoadenitis.
Mouse Models of Primary Sjogren's Syndrome.
This review focuses on recent mouse models of primary SjS xerostomia and describes them under three categories of spontaneous, genetically engineered, and experimentally induced models.
Deficiency of Act1, a critical modulator of B cell function, leads to development of Sjögren's syndrome
It is demonstrated that mice deficient in Act1 developed systemic autoimmune disease with histological and serological features of human Sjögren's syndrome (SS), in association with systemic lupus erythematosus‐like nephritis.
Can B cell epitopes of 60 kDa Ro distinguish systemic lupus erythematosus from Sjögren's syndrome?
The present study finds the epitope defined by residues 171–190 is associated with anti-60 kDa Ro without anti-La, regardless of diagnosis, and the fine specificity of antibody binding to 60 k da Ro varies according to the presence of anti- La, not to the diagnosis of either SLE or SS.
The epidemiology of Sjögren’s syndrome
The aim of this review is to understand the reported incidence and prevalence on pSS and sSS, the frequency of autoantibodies, and the risk of malignancy, which has been associated with pSS, taking into account the different classification criteria used.