B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren’s Syndrome

@article{Zheng2017BCA,
  title={B Cells Are Indispensable for a Novel Mouse Model of Primary Sj{\"o}gren’s Syndrome},
  author={Junfeng Zheng and Qiaoniang Huang and Renliang Huang and Fengyuan Deng and Xiaoyang Yue and Junping Yin and Wenjie Zhao and Yan Chen and Lifang Wen and Jun Zhou and R. Huang and Gabriela Riemekasten and Zuguo Liu and Frank Petersen and Xinhua Yu},
  journal={Frontiers in Immunology},
  year={2017},
  volume={8}
}
Primary Sjögren’s syndrome (pSS) is characterized by a panel of autoantibodies, while it is not clear whether B cells and autoantibodies play an essential role in pathogenesis of the disease. Here, we report a novel mouse model for pSS which is induced by immunization with the Ro60_316-335 peptide containing a predominant T cell epitope. After immunization, mice developed several symptoms mimicking pSS, including a decreased secretion of tears, lymphocytic infiltration into the lacrimal glands… 
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TLDR
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The expression and biological functions of IL-38 are discussed, especially the role in rheumatic autoimmune diseases, and potential for theoretical basis for clinical trials and drug development in the future is given.
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