B Cell Reconstitution after Rituximab Treatment in Idiopathic Nephrotic Syndrome.

@article{Colucci2016BCR,
  title={B Cell Reconstitution after Rituximab Treatment in Idiopathic Nephrotic Syndrome.},
  author={M. Colucci and R. Carsetti and S. Cascioli and F. Casiraghi and A. Perna and L. Rav{\`a} and B. Ruggiero and F. Emma and M. Vivarelli},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2016},
  volume={27 6},
  pages={
          1811-22
        }
}
The pathogenesis of nephrotic syndrome is unclear. However, the efficacy of rituximab, a B cell-depleting antibody, in nephrotic syndrome suggests a pathogenic role of B cells. In this retrospective study, we determined by flow cytometry levels of B and T cell subpopulations before and after rituximab infusion in 28 pediatric patients with frequently relapsing or steroid-dependent nephrotic syndrome. At baseline, patients had lower median percentages of transitional and mature B cells than age… Expand
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