B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.

@article{Polverino2015BCF,
  title={B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease.},
  author={F. Polverino and B. Cosio and J. Pons and Maria E. Laucho-Contreras and P. Tejera and A. Iglesias and {\'A}. R{\'i}os and A. Jahn and J. Sauleda and M. Divo and V. Pinto-Plata and L. Sholl and I. Rosas and A. Agust{\'i} and B. Celli and C. Owen},
  journal={American journal of respiratory and critical care medicine},
  year={2015},
  volume={192 6},
  pages={
          695-705
        }
}
RATIONALE Patients with chronic obstructive pulmonary disease (COPD) have increased pulmonary lymphoid follicle (LF) counts. B cell-activating factor of tumor necrosis factor family (BAFF) regulates B cells in health, but its role in COPD pathogenesis is unclear. OBJECTIVES To determine whether BAFF expression in pulmonary LFs correlates with COPD severity, LF size or number, and/or readouts of B-cell function in LFs. METHODS We correlated BAFF immunostaining in LFs in lung explants or… Expand
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