B-Cell-Activating Factor and Autoimmune Myasthenia Gravis

@inproceedings{Ragheb2011BCellActivatingFA,
  title={B-Cell-Activating Factor and Autoimmune Myasthenia Gravis},
  author={Samia Ragheb and Robert P. Lisak},
  booktitle={Autoimmune diseases},
  year={2011}
}
BAFF is a potent B-cell survival factor, and it plays an essential role in B-cell homeostasis and B-cell function in the periphery. Both normal and autoreactive B cells are BAFF dependent; however, excess BAFF promotes the survival, growth, and maturation of autoreactive B cells. When overexpressed, BAFF protects B cells from apoptosis, thereby contributing to autoimmunity. Three independent studies have shown higher BAFF levels in the circulation of MG patients. BAFF may play an important role… CONTINUE READING

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