B-50 (GAP-43) Immunoreactivity Is Rarely Detected within Intact Catecholaminergic and Serotonergic Axons Innervating the Brain and Spinal Cord of the Adult Rat, but Is Associated with These Axons Following Lesion

@article{Alonso1995B50I,
  title={B-50 (GAP-43) Immunoreactivity Is Rarely Detected within Intact Catecholaminergic and Serotonergic Axons Innervating the Brain and Spinal Cord of the Adult Rat, but Is Associated with These Axons Following Lesion},
  author={G{\'e}rard Alonso and J L Ridet and AB. Oestreicher and Willem Hendrik Gispen and Alain Privat},
  journal={Experimental Neurology},
  year={1995},
  volume={134},
  pages={35-48}
}
The persistence of high levels of B-50 (GAP-43) in fibers innervating various regions of the adult central nervous system is generally thought to characterize neuronal systems capable of undergoing morphological plasticity. In a recent series of in situ hybridization studies, it has been shown that most catecholaminergic and serotonergic neurons of the adult rat brain express high levels of B-50 mRNA. The present study addresses the question whether high expression of B-50 mRNA in the… CONTINUE READING

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