B-50/GAP-43 in neuronal development and repair.

  title={B-50/GAP-43 in neuronal development and repair.},
  author={Willem Hendrik Gispen and Johannes Boonstra and Pierre N. E. de Graan and Frans G. I. Jennekens and AB. Oestreicher and Peter C. Schotman and Loes H. Schrama and Joost Verhaagen and Frank L. Margolis},
  journal={Restorative neurology and neuroscience},
  volume={1 3},
The protein kinase C substrate B-50 is identical to the growth-associated protein GAP-43. Although as yet no causal relationship has been established between B-50/GAP-43 and neurite outgrowth, evidence accumulates that the function of the protein relates to neuronal plasticity. Stimulation of PC12 cells by NGF results in translocation of the protein from cytosolic stores to the membrane of newly formed neurite-like extensions. The protein is associated with the inner leaflet of the growth cone… CONTINUE READING