B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis.

@article{Rosenfeld2015B1bCS,
  title={B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis.},
  author={Sam M. Rosenfeld and Heather M Perry and Ayelet Gonen and Thomas A. Prohaska and Prasad Srikakulapu and Sukhdeep Grewal and Deepanjana Das and Chantel C. McSkimming and Angela M Taylor and Sotirios Tsimikas and Timothy Bender and Joseph L. Witztum and Coleen A. McNamara},
  journal={Circulation research},
  year={2015},
  volume={117 3},
  pages={
          e28-39
        }
}
RATIONALE B cells contribute to atherosclerosis through subset-specific mechanisms. Whereas some controversy exists about the role of B-2 cells, B-1a cells are atheroprotective because of secretion of atheroprotective IgM antibodies independent of antigen. B-1b cells, a unique subset of B-1 cells that respond specifically to T-cell-independent antigens, have not been studied within the context of atherosclerosis. OBJECTIVE To determine whether B-1b cells produce atheroprotective IgM… CONTINUE READING
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