B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production

@inproceedings{Baumgarth2016B1CH,
  title={B-1 Cell Heterogeneity and the Regulation of Natural and Antigen-Induced IgM Production},
  author={Nicole Baumgarth},
  booktitle={Front. Immunol.},
  year={2016}
}
A small subset of B cells, termed B-1 cells, with developmental origins, phenotypes, and functions that are distinct from those of conventional B cells exist in mice. It contributes the vast majority of spontaneously produced "natural" IgM. Natural IgM is constitutively produced, even in the absence of microbiota, and fulfills many distinct functions in tissue homeostasis and host defense. B-1 cells also respond with IgM production to innate signals and pathogen exposure, while maintaining… CONTINUE READING
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