B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity.

@article{Szczepanik2003B1BC,
  title={B-1 B cells mediate required early T cell recruitment to elicit protein-induced delayed-type hypersensitivity.},
  author={Marian Szczepanik and Moe Akahira-Azuma and Krzysztof Bryniarski and Ryohei F. Tsuji and Ivana Kawikova and Wlodzimierz Ptak and Claudia Kiener and R{\'e}gis de Albuquerque Campos and Philip W. Askenase},
  journal={Journal of immunology},
  year={2003},
  volume={171 11},
  pages={6225-35}
}
We define the initiation of elicited delayed-type hypersensitivity (DTH) as a series of processes leading to local extravascular recruitment of effector T cells. Responses thus have two sequential phases: 1) 2-h peaking initiation required for subsequent recruitment of T cells, and 2) the late classical 24-h component mediated by the recruited T cells. We analyzed DTH initiation to protein Ags induced by intradermal immunization without adjuvants. Ag-spceific initiating cells are present by 1… CONTINUE READING
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