B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen

@inproceedings{Puga2011BhelperNS,
  title={B–helper neutrophils stimulate immunoglobulin diversification and production in the marginal zone of the spleen},
  author={Irene Puga and Montserrat Cols and Carolina M. Barra and Bing He and Linda Cassis and Maurizio Gentile and Laura Comerma and Alejo Chorny and Meimei Shan and Weifeng Xu and Giuliana Magri and Daniel M. Knowles and Wayne Tam and April Chiu and James B Bussel and S Villanueva Serrano and Jose Antonio Lorente and Beatriz Bellosillo and Josep Lloreta and N{\'u}ria Juanpere and Francesc Alameda and Teresa Bar{\'o} and Cristina D{\'i}az de Heredia and Nuria T Toran and Albert Catal{\'a} and Montserrat Torrebadell and Cl{\`a}udia Fortuny and Vict{\`o}ria Cus{\'i} and Carmen Carreras and George A Diaz and J Magarian Blander and C. M. Farber and Guido Silvestri and Charlotte Cunningham-Rundles and Michaela Calvillo and Carlo Dufour and Lucia Dora Notarangelo and Vassilios Lougaris and Alessandro Plebani and Jean Casanova and Stephanie C. Ganal and Andreas Diefenbach and Juan I Ar{\'o}stegui and Manel Juan and Jordi Yag{\"u}e and Nizar Mahlaoui and Jean Donadieu and Kang Chen and Andrea Cerutti},
  booktitle={Nature Immunology},
  year={2011}
}
Neutrophils use immunoglobulins to clear antigen, but their role in immunoglobulin production is unknown. Here we identified neutrophils around the marginal zone (MZ) of the spleen, a B cell area specialized in T cell–independent immunoglobulin responses to circulating antigen. Neutrophils colonized peri-MZ areas after postnatal mucosal colonization by microbes and enhanced their B cell–helper function after receiving reprogramming signals, including interleukin 10 (IL-10), from splenic… CONTINUE READING
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