B‐vitamins reduce the long‐term risk of depression after stroke: The VITATOPS‐DEP trial

@article{Almeida2010BvitaminsRT,
  title={B‐vitamins reduce the long‐term risk of depression after stroke: The VITATOPS‐DEP trial},
  author={Osvaldo P. Almeida and Kylie Marsh and Helman Alfonso and Leon Flicker and Timothy M. E. Davis and Graeme J. Hankey},
  journal={Annals of Neurology},
  year={2010},
  volume={68}
}
The consumption of certain B‐vitamins through diet or supplementation decreases the total plasma concentration of homocysteine (tHcy) and may enhance response to standard antidepressant treatment. It is unclear if treatment with B‐vitamins can reduce the long‐term prevalence of depression in people at risk, such as stroke survivors. The purpose of this research was to determine if treatment with B‐vitamins reduces the hazard of poststroke depression compared with placebo. 
View on Wiley
download.xuebalib.com
88 Citations
Highly Influential Citations
4
Background Citations
24
Methods Citations
2
Results Citations
4

88 Citations

Citation Type

Citation Type

Aspirin decreases the risk of depression in older men with high plasma homocysteine
TLDR
The results of this study indicate that older men with high tHcy who use aspirin have lower risk of depression, and suggest that antiplatelet therapy may be an effective preventive or management strategy for these cases.
Effect of long-term supplementation with folic acid and B vitamins on risk of depression in older women
TLDR
Long-term, high-dose, daily supplementation with folic acid and vitamins B6 and B12 did not reduce overall depression risk in mid-life and older women.
What is the role of B-vitamins in stroke prevention in Pakistan?
TLDR
The VITATOPS trial was undertaken to test whether this reduction in homocysteine with vitamin supplementation translates into actual reduction in recurrent vascular events in patients with recent stroke (ischaemic or haemorrhagic) or TIA.
B‐vitamins for neuroprotection: Narrowing the evidence gap
TLDR
Despite some encouraging trials showing benefit of B‐vitamins for slowing brain atrophy and cognitive decline, the majority of these studies have not demonstrated that B‐ vitamin supplementation has protective or therapeutic cognitive benefit.
The role of micronutrients in the rehabilitation of patients after acute cerebrovascular accident
The broad benefits of vitamin and mineral supplementation can improve rehabilitation outcomes in patients with stroke. In this aspect, the most compelling evidence exists for vitamin C, vitamin E,…
Effects of Two-Year Vitamin B12 and Folic Acid Supplementation on Depressive Symptoms and Quality of Life in Older Adults with Elevated Homocysteine Concentrations: Additional Results from the B-PROOF Study, an RCT
TLDR
Two-year supplementation with vitamin B12 and folic acid in older adults with hyperhomocysteinemia showed that lowering Hcy concentrations does not reduce depressive symptoms, but it may have a small positive effect on HR-QoL.
Current evidence linking nutrition with brain health in ageing
TLDR
There is clearer evidence to support a role for folate and related B vitamins in slowing the progression of cognitive decline and possibly reducing the risk of depression in ageing.
The MooDFOOD project: Prevention of depression through nutritional strategies
TLDR
This approach will provide insight into the causality of the link between diet and depression, and underlying pathways; it will also identify which modifications related to diet and dietary behaviour lead to beneficial changes in depression risk and lower the environmental burden of the diet.
Acute vitamin B12 supplementation evokes antidepressant response and alters Ntrk-2
Meta-analysis reveals protective effects of vitamin B on stroke patients
TLDR
It is suggested that vitamin B supplementation presents a potential addition to the armamentarium for the management of acute stroke patients.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 50 REFERENCES
The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life
TLDR
The results of this trial will clarify whether the systematic use of B-vitamins improves the response of older adults to standard antidepressant treatment and have implications for clinical practice and health policy development.
VITATOPS, the VITAmins TO Prevent Stroke Trial: Rationale and Design of a Randomised Trial of B-Vitamin Therapy in Patients with Recent Transient Ischaemic Attack or Stroke (NCT00097669) (ISRCTN74743444)
  • G. Hankey, A. Algra, +47 authors S. Song
  • Medicine
    International journal of stroke : official journal of the International Stroke Society
  • 2007
TLDR
VITATOPS aims to recruit and follow-up 8000 patients and provide a reliable estimate of the safety and effectiveness of folic acid, vitamin B12, and vitamin B6 supplementation in reducing recurrent serious vascular events among a wide range of patients with TIA and stroke throughout the world.
Efficacy of folic acid supplementation in stroke prevention: a meta-analysis
Homocysteine and depression in later life.
TLDR
The triangular association between the MTHFR genotype, tH Cy, and depression implies that higher concentrations of tHcy increase the risk of depression and that lowering tHCy by 0.19 mg/L could reduce the odds of depression by about 20%.
Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia.
TLDR
The tHcy-lowering effect of B vitamins was maximal in those who had low B12 or high tH Cy levels, and community-dwelling older men, who are likely to be deficient in B 12 or have hyperhomocysteinaemia, may be most likely to benefit from treatment with B vitamins.
No effect of vitamin B-12 treatment on cognitive function and depression: a randomized placebo controlled study.
Folic acid enhances lithium prophylaxis.
Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study.
TLDR
The association of vitamin B(12) and folate with depressive disorders may have different underlying mechanisms, whereas the relation with folate is due to physical comorbidity.
Vitamins B12, B6, and folic acid for onset of depressive symptoms in older men: results from a 2-year placebo-controlled randomized trial.
TLDR
The results of this study showed that treatment with B(12), folic acid, and B(6) is no better than placebo at reducing the severity of depressive symptoms or the incidence of clinically significant depression over a period of 2 years in older men.
Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.
...
1
2
3
4
5
...