B‐lymphocyte contributions to human autoimmune disease

@article{Yanaba2008BlymphocyteCT,
  title={B‐lymphocyte contributions to human autoimmune disease},
  author={Koichi Yanaba and J. D. Bouaziz and Takashi Matsushita and Cynthia M. Magro and E. William St.Clair and Thomas F. Tedder},
  journal={Immunological Reviews},
  year={2008},
  volume={223}
}
Summary: Autoimmunity results from abnormal B‐ and T‐cell recognition of self‐antigens, which leads to autoantibody production in many cases. Autoantibodies produced by B‐cell‐derived plasma cells provide diagnostic markers for autoimmunity but also contribute significantly to disease pathogenesis. As discussed in this review, the therapeutic benefit of depleting B cells in mice and humans has refocused attention on B cells and their role in autoimmunity beyond autoantibody production. B cells… 

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