B‐CAM/LU expression and the role of B‐CAM/LU activation in binding of low‐ and high‐density red cells to laminin in sickle cell disease

@article{Zen2004BCAMLUEA,
  title={B‐CAM/LU expression and the role of B‐CAM/LU activation in binding of low‐ and high‐density red cells to laminin in sickle cell disease},
  author={Q. Zen and M. Batchvarova and Christina Twyman and C. Eyler and Huiling Qiu and Laura De Castro and M. Telen},
  journal={American Journal of Hematology},
  year={2004},
  volume={75}
}
  • Q. Zen, M. Batchvarova, +4 authors M. Telen
  • Published 2004
  • Medicine, Biology
  • American Journal of Hematology
  • Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over‐express the high‐affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B‐CAM/LU). This receptor has recently been shown to undergo activation in vitro through a protein kinase A‐dependent mechanism. Low‐density SS RBC express two‐thirds more B‐CAM/LU than high‐density SS RBC. However, high‐density SS RBC have been identified as most adherent to laminin under flow conditions. We… CONTINUE READING
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