• DOI:10.1002/AJH.10442
Corpus ID: 25313713

B‐CAM/LU expression and the role of B‐CAM/LU activation in binding of low‐ and high‐density red cells to laminin in sickle cell disease

@article{Zen2004BCAMLUEA,
  title={B‐CAM/LU expression and the role of B‐CAM/LU activation in binding of low‐ and high‐density red cells to laminin in sickle cell disease},
  author={Q. Zen and M. Batchvarova and Christina Twyman and C. Eyler and Huiling Qiu and Laura De Castro and M. Telen},
  journal={American Journal of Hematology},
  year={2004},
  volume={75}
}

Q. Zen, M. Batchvarova, +4 authors M. Telen

Published 2004

Medicine, Biology

American Journal of Hematology

Red blood cells from patients with sickle cell disease (SS RBC) adhere to laminin and over‐express the high‐affinity laminin receptor basal cell adhesion molecule/Lutheran protein (B‐CAM/LU). This receptor has recently been shown to undergo activation in vitro through a protein kinase A‐dependent mechanism. Low‐density SS RBC express two‐thirds more B‐CAM/LU than high‐density SS RBC. However, high‐density SS RBC have been identified as most adherent to laminin under flow conditions. We… CONTINUE READING

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