Azulene incorporation and release by hydrogel containing methacrylamide propyltrimenthylammonium chloride, and its application to soft contact lens.

  title={Azulene incorporation and release by hydrogel containing methacrylamide propyltrimenthylammonium chloride, and its application to soft contact lens.},
  author={Rei Uchida and Takao Sato and Haruyasu Tanigawa and Kenjiro Uno},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={92 3},
  • R. Uchida, Takao Sato, K. Uno
  • Published 30 October 2003
  • Materials Science, Chemistry
  • Journal of controlled release : official journal of the Controlled Release Society
Application of polymer gels containing side-chain phosphate groups to drug-delivery contact lenses
Hydrogels that contain phosphate groups in side chains were studied for their usefulness in drug-delivery soft contact lenses and suggested that amide groups and phosphate groups must be introduced into the polymer in equimolar amounts to give the necessary polymer–drug interaction.
Improving the loading and release of NSAIDs from pHEMA hydrogels by copolymerization with functionalized monomers.
To enhance the potential of pHEMA hydrogels as nonsteroidal anti-inflammatory drugs (NSAIDs) delivery systems, 4-vinyl-pyridine (VP) and N-(3-aminopropyl) methacrylamide (APMA) were incorporated to the network.
Cyclodextrin-containing hydrogels for contact lenses as a platform for drug incorporation and release.
Synthesis and characterization of new silyl cross‐linking agent for drug delivery system
New crosslinking reagent that has silyl group together with ethyl hydroxyl methacrylate was successfully synthesized. Network polymers with this crosslinked reagent, methacrylic acid, and silyl
Preparation and Evaluation of a Contact Lens Vehicle for Puerarin Delivery
The results showed that incorporation of poly-N-vinylpyrrolidone (PVP) component in the hydrogels caused increase of ESR and decrease of tensile strength, and co-polymerization of MA monomer in the Hydrogel led to a slight drop of E SR and improved tensilestrength of hydrogel.
Imprinted soft contact lenses as norfloxacin delivery systems.
Effect of anionic/siloxy groups on the release of ofloxacin from soft contact lenses
It is shown that the hydrogels that included side-chain ionic groups and silyl groups were useful materials to prepare drug delivery contact lenses and could functionally retain a drug if an ionic substituent was present.
Physical Entrapment of Hyaluronic Acid During Synthesis Results in Extended Release From Model Hydrogel and Silicone Hydrogel Contact Lens Materials
Assessing the duration of hyaluronic acid release from model contact lens materials when HA was physically incorporated into the hydrogel during synthesis found that it may be released for extended periods of time of up to 7 weeks, which leads to decreased protein adsorption in general.


Timolol uptake and release by imprinted soft contact lenses made of N,N-diethylacrylamide and methacrylic acid.
Tear Exchange and Oxygen Reservoir Effects in Silicone Hydrogel Systems
The statistically significant hypoxia reduction observed with the SH lens insertion and blinking indicates the additive presence of two factors: (1) a lens reservoir effect caused by theSH lens and (2) a bulk-flow tear exchange effect cause by blinking.
Use of hydrophilic contact lenses to increase ocular penetration of topical drugs.
Bionite lenses, either untreated or pretreated with fluorescein, markedly increase the concentration of this drug in the anterior segment of the eye, suggesting that these lenses may be useful adjuncts in attaining and maintaining high drug concentrations in the eye without the use of frequent topical medication.
Polymeric systems for controlled drug release.
Kevin Shakesheff investigates new methods of engineering polymer surfaces and the application of these engineered materials in drug delivery and tissue engineering.
Retrospective Case Series of Therapeutic Applications of Lotrafilcon A Silicone Hydrogel Soft Contact Lenses
The high-oxygen permeable (Dk) lotrafilcon A lens met or exceeded the outcomes reported from historic reports of therapeutic applications of low-Dk soft contact lenses, and indicates that success may be improved with the lotra Filcon A high- Dk lens.
Ophthalmic drug delivery systems
Fundamental considerations: overview of ocular drug delivery, Sreeraj Macha, Patrick M. Hughes, and Ashim K. Mitra membrane transport processes in the eye, Gangadhar Sunkara and Uday Kompella general
Hydrophilic Gels for Biological Use
PLASTICS to-day enjoy wide use in many fields, and it is natural that the possibility of their employment in permanent contact with living tissues has been seriously considered. A study of the
Drug delivery through soft contact lenses.
  • M. R. Jain
  • Medicine
    The British journal of ophthalmology
  • 1988
Clinical studies were conducted on 466 patients waiting for senile cataract surgery and receiving chloromycetin, gentamicin, or carbenicillin subconjunctivally and through New Sauflon 70 and New Sau Flon 85 lenses to provide therapeutically effective levels against most of the common ocular pathogens.
Protection of the ocular surface after keratoprosthesis surgery: the role of soft contact lenses.
A soft contact lens can be of considerable protective value to the cornea surrounding a keratoprosthesis.
Bilateral Keratoconus after LASIK in a Keratoconus Patient
A finding of inferior steepening on corneal topography examination should be regarded as a contraindication to the LASIK procedure.