Azithromycin versus standard care in patients with mild-to-moderate COVID-19 (ATOMIC2): an open-label, randomised trial
@article{Hinks2021AzithromycinVS, title={Azithromycin versus standard care in patients with mild-to-moderate COVID-19 (ATOMIC2): an open-label, randomised trial}, author={Timothy S. C. Hinks and Lucy Cureton and Ruth Knight and Ariel Wang and Jennifer L. Cane and Vicki S Barber and Joanna Black and Susan J Dutton and James Melhorn and Maisha F. Jabeen and Phil Moss and Rajendar Garlapati and Tanya Baron and Graham Johnson and Fleur Cantle and David Clarke and Samer Elkhodair and Jonathan Underwood and Daniel S Lasserson and Ian D. Pavord and Sophie B. Morgan and Duncan B. Richards}, journal={The Lancet. Respiratory Medicine}, year={2021}, volume={9}, pages={1130 - 1140} }
39 Citations
Azithromycin use and outcomes in patients with COVID-19: an observational real-world study
- Medicine, BiologyInternational Journal of Infectious Diseases
- 2022
Azithromycin in patients with COVID-19: a systematic review and meta-analysis
- MedicineThe Journal of antimicrobial chemotherapy
- 2021
The results presented in this systematic review and meta-analysis do not support the use of azithromycin in the management of CO VID-19 and future research on treatment for patients with COVID-19 may need to focus on other drugs.
Outcomes of patients with severe and critical COVID-19 treated with dexamethasone: a prospective cohort study
- MedicineEmerging microbes & infections
- 2021
Treatment with corticosteroids was associated with reduced in-hospital mortality among patients with severe and critical COVID-19, including those on IMV, and CS-T was independently associated with lower mortality.
Failed clinical trials on COVID-19 acute respiratory distress syndrome in hospitalized patients: common oversights and streamlining the development of clinically effective therapeutics
- MedicineExpert opinion on investigational drugs
- 2022
Future clinical trials should be designed to standardize clinical approaches, with appropriate organization, patient selection, addition of control groups, and careful identification of disease phase to reduce heterogeneity and bias and should rely on the integration of scientific societies to promote a consensus on interpretation of the data and recommendations for optimal COVID-19 therapies.
Comparative effectiveness of pharmacological interventions on mortality and the average length of hospital stay of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
- MedicineExpert review of anti-infective therapy
- 2021
Mortality and the average length of hospital stay of COVID-19 patients were significantly reduced with anti-inflammatory drugs, and no effectiveness was found in other pharmacological interventions.
Antibiotic Use and Bacterial Infection in COVID-19 Patients in the Second Phase of the SARS-CoV-2 Pandemic: A Scoping Review
- Medicine, BiologyAntibiotics
- 2022
The antibiotic prescribing rate for COVID-19 patients (June 2020–March 2021) was found to have declined overall, and the most frequently prescribed antibiotics were all on the “Watch” list of the WHO AWaRe antibiotics classification.
Early Outpatient Treatment of COVID-19: A Retrospective Analysis of 392 Cases in Italy
- MedicinemedRxiv
- 2022
The use of individual drugs and drug combinations described in this study appears effective and safe, as indicated by the few and mild ADR reported, and the effectiveness and safety of COVID-19 early treatment in the real world.
Host‐modifying drugs against COVID‐19: some successes, but not yet the breakthrough
- Medicine, BiologyEnvironmental microbiology
- 2021
The trials showed a clear need for new drugs instead of repurposed drugs and drugs that specifically target the SARS‐CoV‐2 virus or the pathology developing in COVID‐19 patients.
COVID-19 Patient Management in Outpatient Setting: A Population-Based Study from Southern Italy
- MedicineJournal of clinical medicine
- 2021
The drug prescribing patterns for CO VID-19 treatment in an outpatient setting from Southern Italy was not supported from current evidence on beneficial therapies for early treatment of COVID-19, thus highlighting the need to implement strategies for improving appropriate drug prescribing in general practice.
Antidepressants for COVID-19: A systematic review
- Psychology, MedicineJournal of Affective Disorders
- 2022
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