Azithromycin treatment increases survival of high-risk corneal allotransplants.

  title={Azithromycin treatment increases survival of high-risk corneal allotransplants.},
  author={Carlos A. Medina and Alexander M Rowe and Hongmin Yun and Jared Evan Knickelbein and Kira L. Lathrop and Robert L Hendricks},
  volume={32 5},
PURPOSE To test the therapeutic efficacy of azithromycin (AZM), a macrolide antibiotic for prolonging murine "high-risk" corneal allograft survival. METHODS Fully major histocompatibility complex-mismatched corneas were transplanted from C57BL/6 donors to BALB/c recipients with suture-induced vascularized high-risk corneal beds. Recipient mice were either not treated or treated with topical AZM, oral AZM, or both. Evaluation of graft vascularization and clarity was performed in a masked… CONTINUE READING
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