Azithromycin-sulfonamide conjugates as inhibitors of resistant Streptococcus pyogenes strains.

  title={Azithromycin-sulfonamide conjugates as inhibitors of resistant Streptococcus pyogenes strains.},
  author={Mirjana Bukvi{\'c} Kraja{\vc}i{\'c} and Predrag Novak and Mario Cindri{\'c} and Karmen Braj{\vs}a and Miljenko Dumi{\'c} and Nedjeljko Kujund{\vz}i{\'c}},
  journal={European journal of medicinal chemistry},
  volume={42 2},
Novel hybrid compounds 6a-6d, conjugates of 15-membered azalides and sulfonamides, i.e. unsubstituted, 4-aryl- and 4-heteroaryl-aminosulfonyl derivatives of 9a-[N'-(phenylcarbamoyl)]-9-deoxo-9-dihydro-9a-aza-9a-homoerythromycin A were synthesized and characterized by IR, one- and two-dimensional NMR spectroscopies and MALDI-TOF and MS/MS mass spectrometry. The new compounds were evaluated in vitro against a panel of sensitive and resistant Gram-positive and Gram-negative bacterial strains. 9a… CONTINUE READING