Azithromycin may inhibit interleukin-8 through suppression of Rac1 and a nuclear factor-kappa B pathway in KB cells stimulated with lipopolysaccharide.

@article{Matsumura2011AzithromycinMI,
  title={Azithromycin may inhibit interleukin-8 through suppression of Rac1 and a nuclear factor-kappa B pathway in KB cells stimulated with lipopolysaccharide.},
  author={Yusuke Matsumura and Akio Mitani and Takayuki Suga and Yosuke Kamiya and Takeshi Kikuchi and Shigehisa Tanaka and Makoto Aino and Toshihide Noguchi},
  journal={Journal of periodontology},
  year={2011},
  volume={82 11},
  pages={1623-31}
}
BACKGROUND Recent studies have shown that the 15-member macrolide antibiotic azithromycin (AZM) not only has antibacterial activity, but also results in the role of immunomodulator. Interleukin (IL)-8 is an important inflammatory mediator in periodontal disease. However, there have been no reports on the effects of AZM on IL-8 production from human oral epithelium. Therefore, we investigated the effects of AZM on IL-8 production in an oral epithelial cell line. METHODS KB cells were… CONTINUE READING
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