Azithromycin in the treatment of Legionella pneumonia requiring hospitalization.


Azithromycin is highly active against Legionella pneumophila and has been shown to be efficacious in animal models and in clinical studies of patients with legionnaires disease. This open, prospective, multicenter trial evaluated azithromycin for the treatment of legionnaires disease. Twenty-five hospitalized patients with community-acquired pneumonia and a positive result of a L. pneumophila serogroup 1 urinary antigen assay received monotherapy with intravenous azithromycin (500 mg/day) for 2-7 days, followed by oral azithromycin (1500 mg administered over the course of 3 or 5 days). The mean total duration of intravenous plus oral therapy was 7.92 days. The overall cure rate among clinically evaluable patients was 95% (20 of 21 patients) at 10-14 days after therapy and 96% (22 of 23 patients) at 4-6 weeks after therapy. The results of this study support previously reported data demonstrating that azithromycin is both safe and efficacious for the treatment of hospitalized patients with legionnaires disease.

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@article{Plouffe2003AzithromycinIT, title={Azithromycin in the treatment of Legionella pneumonia requiring hospitalization.}, author={Joseph F Plouffe and Robert F . Breiman and Barry S. Fields and Mark Herbert and Jill A Inverso and Charles Knirsch and Antonia Kolokathis and Tom Marrie and Lindsay E . Nicolle and Douglas B Schwartz}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={2003}, volume={37 11}, pages={1475-80} }