Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.

@article{Mulet2009AzithromycinIP,
  title={Azithromycin in Pseudomonas aeruginosa biofilms: bactericidal activity and selection of nfxB mutants.},
  author={Xavier Mulet and Mar{\'i}a Dolores Maci{\'a} and Ana L{\'u}cia Mena and Carlos Juan and J-L. Perez and Antonio Oliver},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 4},
  pages={
          1552-60
        }
}
Azithromycin (AZM) has shown promising results in the treatment of Pseudomonas aeruginosa chronic lung infections such as those occurring in cystic fibrosis (CF) patients. We evaluated the effect of hypermutation and alginate hyperproduction on the bactericidal activity and resistance development to AZM in P. aeruginosa biofilms. Strains PAO1, its microcA mutant (PAOMA), and their respective mutS-deficient hypermutable derivatives (PAOMS and PAOMSA) were used. Biofilms were incubated with… CONTINUE READING

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