Azithromycin in Hospitalised Patients with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

  title={Azithromycin in Hospitalised Patients with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial},
  author={Peter W. Horby and Alistair J. Roddick and Enti Spata and Natalie Staplin and Jonathan R. Emberson and Guilherme Pessoa-Amorim and Leon Peto and Mark Campbell and Christopher E. Brightling and Benjamin Prudon and David R. Chadwick and Andrew P. Ustianowski and Abdul Ashish and Stacy Todd and Bryan Yates and Robert Christians Buttery and S. Scott and Diego Maseda and John Kenneth Baillie and M. H. Buch and Lucy C. Chappell and Jeremy N Day and Saul N. Faust and Thomas F. Jaki and Katie Jeffery and Edmund Juszczak and Wei Shen Lim and Alan A. Montgomery and Andrew D. Mumford and Kathryn M. Rowan and Guy E. Thwaites and Marion M. Mafham and Richard Haynes and Martin J Landray},
Background: Azithromycin has been proposed as a treatment for COVID-19 on the basis of its immunomodulatory actions. We evaluated the efficacy and safety of azithromycin in hospitalised patients with COVID-19. Methods: In this randomised, controlled, open-label, adaptive platform trial, several possible treatments were compared with usual care in patients hospitalised with COVID-19 in the UK. Eligible and consenting patients were randomly allocated to either usual standard of care alone or… Expand
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Medikamentöse Therapie bei COVID-19 mit Bewertung durch die Fachgruppe COVRIIN am Robert-Koch-Institut
Autoren und wird Ihre Fragen und Anregungen weiterleiten. Stand: 08.07.2021; DOI 10.25646/7743.10 1 Medikamentöse Therapie bei COVID-19 mit Bewertung durch die Fachgruppe COVRIIN am RobertExpand


Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
  • Peter W Marion Jennifer L Louise Natalie Jonathan Adrian Horby Mafham Bell Linsell Staplin Emberson Palfree, P. Horby, +24 authors M. Landray
  • Medicine
  • The Lancet
  • 2020
In patients admitted to hospital with COVID-19, lopinavir–ritonavir was not associated with reductions in 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death. Expand
Safety and effectiveness of azithromycin in patients with COVID-19: An open-label randomised trial
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In patients hospitalized with COVID-19, hydroxychloroquine was not associated with reductions in 28-day mortality but was associated with an increased length of hospital stay and increased risk of progressing to invasive mechanical ventilation or death. Expand
Hydroxychloroquine with or without Azithromycin in Mild-to-Moderate Covid-19
Among patients hospitalized with mild-to-moderate Covid-19, the use of hydroxychloroquine, alone or with azithromycin, did not improve clinical status at 15 days as compared with standard care. Expand
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Combination treatment reduced both 30‐ and 90‐day mortality and length of hospital stay and the virus titer and PSI and the NPA specimens with NIRV quasispecies ≥ 5% were significantly lower in the combination treatment group. Expand
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Whether the effect of corticosteroids compared with usual care or placebo on mortality up to 28 days after randomization varies between subgroups related to treatment characteristics, disease severity at the time of randomization, patient characteristics, or risk of bias is examined. Expand
Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19
In this observational study involving patients with Covid-19 who had been admitted to the hospital, hydroxychloroquine administration was not associated with either a greatly lowered or an increased risk of the composite end point of intubation or death. Expand
Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study
In study participants, mortality was high, independent risk factors were increasing age, male sex, and chronic comorbidity, including obesity, and the importance of pandemic preparedness and the need to maintain readiness to launch research studies in response to outbreaks is shown. Expand