Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta.

@article{Bosnar2009AzithromycinAC,
  title={Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta.},
  author={Martina Bosnar and Berislav Bo{\vs}njak and Snje{\vz}ana {\vC}u{\vz}i{\'c} and Bo{\vs}ka Hrva{\vc}i{\'c} and Nikola J Marjanovi{\'c} and Ines Glojnari{\'c} and Ognjen {\vC}uli{\'c} and Michael John Parnham and Vesna Erakovi{\'c} Haber},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={331 1},
  pages={104-13}
}
Macrolide antibiotics possess immunomodulatory/anti-inflammatory properties. These properties are considered fundamental for the efficacy of macrolide antibiotics in the treatment of chronic inflammatory diseases like diffuse panbronchiolitis and cystic fibrosis. However, the molecular mechanisms and cellular targets of anti-inflammatory/immunomodulatory macrolide activity are still not fully understood. To describe anti-inflammatory effects of macrolides in more detail and to identify… CONTINUE READING