Azithromycin Combination Therapy with Artesunate or Quinine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Adults: A Randomized, Phase 2 Clinical Trial in Thailand

@article{Noedl2006AzithromycinCT,
  title={Azithromycin Combination Therapy with Artesunate or Quinine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Adults: A Randomized, Phase 2 Clinical Trial in Thailand},
  author={Harald Noedl and Srivicha Krudsood and Kobsiri Chalermratana and Udomsak Silachamroon and Wattana Leowattana and Noppadon Tangpukdee and Sornchai Looareesuwan and R. S. Miller and Mark M Fukuda and Krisada Jongsakul and Sabaithip Sriwichai and Jacqueline Rowan and Helen Bhattacharyya and Colin Ohrt and Charles Knirsch},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2006},
  volume={43 10},
  pages={
          1264-71
        }
}
BACKGROUND Because antimalarial drug resistance is spreading, there is an urgent need for new combination treatments for malaria, which kills >1 million people every year. Azithromycin is a macrolide antibiotic that is particularly attractive as an antimalarial because of its safety in children and the extensive experience with its use during pregnancy. METHODS We undertook a randomized, controlled, 28-day inpatient trial involving patients with acute, uncomplicated Plasmodium falciparum… CONTINUE READING
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