Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys.

@article{Puri2000AzithromycinAP,
  title={Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys.},
  author={Sunil K. Puri and Naresh Singh},
  journal={Experimental parasitology},
  year={2000},
  volume={94 1},
  pages={8-14}
}
The spectrum of antimalarial activity of the new macrolide antibiotic azithromycin was evaluated against blood- and sporozoite-induced infections with a chloroquine-resistant strain of Plasmodium yoelii nigeriensis (N-67) in Swiss mice and with simian parasite Plasmodium cynomolgi B in rhesus monkeys. Against experimental rodent malaria, a 70 mg/kg/day dose showed curative blood-schizontocidal activity in a four-dose regimen administered orally from day 0 to day 3 or from day 2 to day 5 to mice… CONTINUE READING

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